(3R,3aS,6R,6aR)-3-(1-Nitroethyl)perhydrofuro[3,2-b]furan-3,6-diol
نویسندگان
چکیده
The mol-ecule of the title compound, C(8)H(13)NO(6), a sucrose derivative, consists of two fused tetra-hydro-furan rings having the cis arrangement at the ring junctions, giving a V-shaped mol-ecule. An intra-molecular O-H⋯O inter-action occurs. Inter-molecular O-H⋯O hydrogen bonds help to stabilize the crystal structure.
منابع مشابه
(3S,3aS,6R,6aR)-2-Oxohexahydrofuro[3,2-b]furan-3,6-diyl dibenzoate
The title compound, C20H16O7, contains a cis-fused γ-lactone tetra-hydro-furan ring system functionalized with two benzo-yloxy groups. Both rings adopt an envelope conformation. The mol-ecule assumes an elongated shape and exibits non-crystallographic C 2 symmetry. The benzo-yloxy groups are almost planar [maximum deviations of 0.0491 (15) and 0.0336 (17) Å for the O atoms] and their mean plane...
متن کامل(3R,3aR,6R,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diyl dibenzoate
The title compound, C20H18O6, prepared from d-mannitol by a two-step procedure, is a functionalized fused bis-tetra-hydro-furan. In the central fragment, consisting of two fused tetra-hydro-furan rings, one O atom and its two adjacent C atoms, a methyl-ene and a bridgehead C atom, are disordered over two sets of sites with an occupancy ratio of 0.735 (9):0.265 (9). In the major component, the r...
متن کاملPractical Synthesis of the Bicyclic Darunavir Side Chain: (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-ol from Monopotassium Isocitrate
A practical synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol-a key intermediate in the synthesis of darunavir-from monopotassium isocitrate is described. The isocitric acid salt, obtained from a high-yielding fermentation fed by sunflower oil, was converted in several steps to a tertiary amide. This amide, along with the compound's ester functionalities, was reduced with lithium aluminu...
متن کامل(2R*,3R*,4aS*,6aR*,11aS*,11bS*)-Methyl 2-acetoxy-11b-hydroxy-3,7-dimethyl-1,2,3,4,4a,5,6,6a,7,11,11a,11b-dodecahydrophenanthro[3,2-b]furan-3-carboxylate
In the title compound, C(22)H(30)O(6), the conformation of the mol-ecule is dictated by an intra-molecular C-H⋯O contact. The crystal structure is stabilized via inter-molecular C-H⋯O, O-H⋯O and C-H⋯π contacts.
متن کاملThree-component synthesis of polysubstituted homoproline analogs.
Tetrasubstituted pyrrolidines representing analogs of homoproline were synthesized by three-component condensation of aryl(heteroaryl)aldehydes, asparagine and N-methylmaleimide (NMM). Compounds with (1S*, 3R*, 3aS*, 6aR*)-configuration at the corresponding carbon positions of the bicyclic pyrrolidine ring could be isolated ona preparative scale.
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عنوان ژورنال:
دوره 66 شماره
صفحات -
تاریخ انتشار 2010